CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies
نویسندگان
چکیده
منابع مشابه
CDR-H3 diversity is not required for antigen recognition by synthetic antibodies.
A synthetic phage-displayed antibody repertoire was constructed with equivalent chemical diversity in the third complementarity-determining regions of the heavy (CDR-H3) and light (CDR-L3) chains, which contrasts with natural antibodies in which CDR-H3 is much more diverse than CDR-L3 due to the genetic mechanisms that generate antibody encoding genes. Surprisingly, the synthetic repertoire yie...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2013
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2012.11.037